Non-functioning pituitary adenomas, not all the same and certainly not boring!

Repetitive perhaps, but certainly not boring

Not boring at all

The element boron is not renowned among biologists, short of a few specialists who know that it is an essential nutrient for plants and an element in boromycin—an antibiotic compound produced by Streptomyces. Yet, on the whole, molecular biologists and, in particular, those in drug development seem to have little use for carbon’s left-hand neighbour in the periodic table. This is about to chang...

ZAC1 and SSTR2 Are Downregulated in Non-Functioning Pituitary Adenomas but Not in somatotropinomas

INTRODUCTION There are few data regarding ZAC1 expression in clinically non-functioning pituitary adenomas (NFPA). Because somatotropinomas and NFPA behave differently with respect to tumor shrinkage during somatostatin analogs (SA) therapy, we sought to compare the ZAC1 and somatostatin receptor (sstr) types 1, 2, 3 and 5 mRNA expression in these two pituitary adenoma subtypes and in normal hu...

Not all injections are the same.

To the Editor: In metaphorical terms, a problem arises when good apples are pooled with bad apples; they all get tarred with the same brush. This principle applies when all studies pertaining to spinal injections of steroids are pooled, as if they are all equal. Subsequently, the lay press publicizes sweeping conclusions such as “injecting any liquid, even plain saline solution, works just as w...

Not all sudden death is the same.

Sudden death as a result of cardiac arrhythmia is probably the most common symptom associated with cardiac disease. It occurs not only in people with known cardiac disease, most notably congestive heart failure, but also in young, apparently healthy individuals who have no apparent structural heart disease. Frequently, in this latter group, these fatal arrhythmias are associated with exercise a...